Search results for "Hybridoma technology"

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Generation of monoclonal antibodies of desired specificity using chimeric polyomavirus-derived virus-like particles.

2005

Foreign protein sequences presented on hamster polyomavirus (HaPyV) major capsid protein VP1-derived virus-like particles (VLPs) have been demonstrated to be highly immunogenic. The current study was aimed to evaluate VP1-derived chimeric VLPs as tools for hybridoma technology to generate monoclonal antibodies (mAbs) of desired specificity. Chimeric VLPs containing inserts of different size and origin were used as immunogens. Chimeric VLPs carrying a 9 amino acid (aa)-long cytotoxic T-cell epitope (STAPPVHNV) of human mucin 1 (MUC1) elicited a strong epitope-specific humoral immune response in mice and promoted the production of MUC1-specific mAbs. From a total of seven mAbs of IgG isotype …

Malemedicine.drug_classvirusesRecombinant Fusion ProteinsImmunologyBlotting WesternEnzyme-Linked Immunosorbent AssayBiologyMonoclonal antibodycomplex mixturesPuumala virusEpitopeEpitopesMiceVirus-like particleAntibody SpecificityAntigens NeoplasmmedicineImmunology and AllergyHamster polyomavirusAnimalsMice Inbred BALB CHybridomasImmunogenicityMucin-1Mucinsvirus diseasesAntibodies MonoclonalDendritic Cellsbiochemical phenomena metabolism and nutritionNucleocapsid ProteinsVirologyMolecular biologyCapsidImmunoglobulin Gbiology.proteinHybridoma technologyCapsid ProteinsAntibodyPolyomavirusEpitope MappingJournal of immunological methods

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